Genetic regulatory signatures underlying islet gene expression and type 2 diabetes, Varshney et al.

The full paper is available here: doi:10.1073/pnas.1621192114

You can follow this link to our dynamic islet eQTL explorer.

The data available here includes chromatin state predictions in various tissues; peak calls made on islet, adipose, and lymphoblastoid tissue data referenced in the paper; and transcription factor footprinting for islet data (ABCU196 and ABE1388).

ABCU196 is Islet 1 from the paper; ABE1388 is Islet 2.

Each subset of the data is available in its own subdirectory, and also in a single file. For example, the ABCU196 footprints are available in individual files by transcription factor in the footprints.abcu196 directory, or all together in footprints.abcu196.tar.gz.

The full cis-eQTL scan results are available in the cis-eQTL-scan directory. Allele 1 is the effect allele.

All of the data available here, except the cis-eQTL scan results, are included in everything.tar.gz.

All coordinates are based on hg19.

Icon  Name                                   Last modified      Size  Description
[PARENTDIR] Parent Directory - [DIR] atacseq_fastqc/ 2018-03-12 23:05 - [DIR] atacseq_IsletMuscleAdiposeGM/ 2017-09-14 16:49 - [DIR] chromatin_states/ 2017-03-13 13:03 - [DIR] cis-eQTL-scan/ 2017-04-21 08:34 - [DIR] footprints.abcu196/ 2017-03-13 13:03 - [DIR] footprints.abe1388/ 2017-03-22 09:53 - [DIR] peaks.broad/ 2017-09-14 17:51 - [DIR] stretchEnhancers_13StateModel/ 2016-12-16 11:37 - [   ] chromatin_states.tar.gz 2017-03-13 12:51 65M [   ] everything.tar.gz 2017-03-13 18:47 3.6G [   ] footprints.abcu196.tar.gz 2017-03-13 12:50 2.3G [   ] footprints.abcu196.updated_2018.tar.gz 2018-05-16 14:12 2.3G [   ] footprints.abe1388.tar.gz 2017-03-13 12:49 1.2G [   ] footprints.abe1388.updated_2018.tar.gz 2018-05-16 14:13 1.2G [   ] peaks.broad.tar.gz 2017-03-13 13:46 16M